Cardio-Metabolic
NEUGAPIN
- In Neuropathic Pain Management
- Pregabalin 75mg with
Methylcobalamin 1500mcg
- Tablets
Pregabalin
- Reduces neurotransmitter release Reduces neuropathic pain
Methylcobalamin
- Promotes Myelination Augment Sensory & Motor function
Key Benefits -
- 72.30/o reduction in Pain score in 2 weeks
- Effect starts within weeks time
- Efficacy and tolerability rated as good to excellent by > 95%
patients
Remyelination
ensures long
term relief
Prevents the
progression of
Neuropathy
Relives painful
Neuropathy
symptoms
- Rebuild
Nerves,
Rejuvenate
GRIT
HEFGINA
- Trimetazidine 35 mg Modified
Release Tablets
Improve L V Function in DM
- In DM, the myocardial glucose utilization is impaired. Leads to
decreased myocyte glucose uptake & high FFA - TMZ Improve L V in diabetics & Improve left ventricular
ejection fraction (L VEF)
Reduce Myocardial Demand
- Switches mitochondrial ATP formation from FFA to Glucose.
(Inhibits 3-ketoacyl coenzyme A thiolase in FFA oxidation) - Glycolysis requires 10%-15% less 02 than FF A oxidation to
yield same ATP
Improve
endothelial
function
Controls ischemia
through intracellular
metabolic changes
Reduces
reperfusion
injury
- Empower
cardiomyocytes
in Angina & MI
patients
Enhances the
duration of
coronary flow.
Reduces MVO & thus O consumption
Reduces Heart
Rate, Prolongs
Diastole
Benziva
- The Primary Adjuvant
- Ivabradine 5mg Tablets
Similar to Beta Blocker
- Reduction in heart rate is similar to that with beta-blockers
Develop Collaterals
Promote development of coronary collaterals
- Minimal effect on myocardial contractility, BP and intracardiac conduction
Powerful Therapy
- In patients who are intolerant or Contraindicated to Beta blockers
- In patients with higher HR & uncontrolled with BB optimum dose
- In Stable
angina &
ACS
- 2
- 2
- Gliclazide 30mg 60mg
Mechanism of Action
- Gliclazide stimulates insulin secretion thought the beta cell
sulphonylurea receptor
Benefits
- Shows gradual improvement in glycemic condition
- Lower the risk of Hypoglycemia
- Reduces risk of cardiovascular disease
- Reduces Oxidative stress, inflammation & bone loss
Reduces
Insulin
Resistance
Decrease expression of
inflammatory markers &
endothelium Dysfunction
Gives
Cardiovascular
Protection
- Revolutionize
diabetes
management
with Gliclazide
SECGLY
- Tablets
- Rosuvastatin 10mg, Ezetimibe 10mg
Benefits
- Ezetimibe inhibits cholesterol absorption
from the small intestine - Improves Vascular Endothelial Dysfunction
in ACS
Reduction in LDL-C
Levels
- Rosuvastatin 10mg / 20mg
Benefits
- Provides LDL-C reduction even in
patients shifted from Atorvastatin - Provides greatest reduction in LDL-C in
women with Hypercholesterolemia - Superior to atorvastatin in the reversion
of coronary Atherosclerotic Plaques
Highest increase in HDL-C
compared to all other
statins at recommended
doses (STELLAR study)
Provides LDL-C reduction
even in patients shifted
from Atorvastatin
Stateze RZ
- Tablets
Stateze R 10 20
- Tablets